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PTGS2 (COX-2) — Rank: 0.97 | Evidence: 1,243 sources

Primary therapeutic target for aspirin. Prostaglandin-endoperoxide synthase 2 catalyzes the conversion of arachidonic acid to prostaglandin H2, a key mediator of inflammation...

KRAS G12C — Rank: 0.94 | Evidence: 987 sources

Oncogenic driver mutation found in ~13% of NSCLC cases. Sotorasib and adagrasib target the GDP-bound inactive state...

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